the features of the muscarinic syndrome are helpfully summarized by the popular mnemonic 'SLUDGEM-BBB': salivation, lacrimation, urination, diarrhea, gastric cramps, emesis, miosis, bronchorrhea, bronchospasm, bradycardia 2.it is characterized by an acute muscarinic syndrome that manifests within hours of initial toxic exposure, and is soon afterwards followed by an acute nicotinic syndrome 2,3.
acute cholinergic crisis and paralysis (type I paralysis).Clinical presentationĪcute organophosphate poisoning leads to three distinct sequential neurological syndromes. It is thought that worldwide, approximately 3 million people are exposed to toxic levels of organophosphates, including approximately 2 million hospitalizations for suicidal ingestion 1. Organophosphate poisoning is common, often as a result of suicidal ingestion (acute high-level exposure) or occupational exposure to pesticides (chronic low-level exposure) 1.
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